Ahcc lymphoma. 5 times increase in natural killer cell activity, and over half had a tumor response. In this installment, Gary Deng, MD, PhD, and Jyothirmai Gubili, MS, focus on active hexose correlated compound (AHCC), which contains polysaccharides extracted from shiitake mushroom mycelia Sep 24, 2025 · The medicinal mushroom supplement AHCC has been studied for boosting the immune system and protecting against cancer. Talk with your healthcare provider before taking AHCC. Aug 7, 2025 · AHCC has been evaluated in over 100 preclinical studies, and 30+ human clinical trials — a substantial portion of these are cancer-related. Aug 20, 2024 · While AHCC is used for these reasons, there isn’t enough research to say that it works. Apr 9, 2025 · AHCC, derived from shiitake mushroom mycelia, is believed to enhance immune responses, as evidenced by its ability to delay tumor development in mouse models of melanoma and lymphoma and improve immune surveillance. Neither the publisher nor the author directly or indirectly dispenses medical advice, nor do they prescribe any Dec 15, 2015 · Active Hexose Correlated Compound (AHCC) is a fermented mushroom extract and immune supplement that has been used to treat a wide range of health conditions. Herbal supplements can interact with some medications and affect how they work. AHCC has been implicated to modulate immune functions and plays a protective role against infection. [12] Active Hexose Correlated Compound (AHCC) has been shown to have many immunostimulatory and anti-cancer activities in mice and in humans. The There is extensive research behind AHCC, from cancer trials to diabetes support. AHCC and GCP were consumed orally by concurrent or sequential use. 8 - 11 The primary active component is acylated α-glucan and contains <0. Studies using rodent models have evaluated the efficacy of AHCC in the incidence and outcomes of cancer, and reducing toxicities associated with treatment. Acute Myeloid Apr 15, 2006 · Abstract. May 29, 2024 · TPS4192Background: β-catenin mutations are present in up to 40% of aHCC pts. Fucoidan inhibited the growth of DLBCL cells in a dose- and time-dependent m … AHCC ® has been used with great success in cancer patients. It is very important for post-operative patients to prevent recurrence and recover their nutritional conditions. Nov 9, 2019 · Therefore, preventing the onset of numerous conditions affecting the elderly, today. In a murine model of CLL, AHCC led to a significant increase in survival time and also enhanced antibody treatment. However, the … What is AHCC? Active Hexose Correlated Compound, also known as AHCC, is a chemical derived from Shiitake mushrooms and other fungi. Choose to download the complete PDF or click to read a summary of each study. On the other hand, AHCC can increase immunoreactivity by up-regulating cytokines such as IL-1, IL-2, IL-12, IFN-gama, TNF-alpha and enhancing the activities of macrophages, LAK and NK cells. It helps in augmentation of the natural immune response and affects immune cell activation and Active hexose correlated compound (AHCC) is a mixture of polysaccharides, amino acids, lipids and minerals derived from cocultured mycelia of several species of Basidiomycete mushrooms. Eleven advanced cancer patients who were given 3 gm per day of AHCC for 1 month in an uncontrolled trial showed a 2. (Kenner p. We showed that compared to pure water treated mice, AHCC Researchers have also studied the anticancer activity of fucoidan in large B-cell lymphoma cells (DL-BCL); [106] the results showed a loss of MMP in the lymphoma cells along with cytochrome c release from their mitochondria and induction of lymphoma cell-specific apoptosis. Small studies show benefits, but more extensive clinical trials are needed before AHCC can be routinely recommended. This article is about the main benefits of the AHCC, its potential side effects, the best time to take it, and more. AHCC has few reported side effects, but it can interact with cancer medications and other drugs that the liver breaks down. These results suggest that AHCC has both direct and indirect effects against CLL and that it may be an effective adjuvant for immune-based therapies. All matters concerning physical and mental health should be supervised by a health practitioner knowl-edgeable in treating that particular condition. Jul 9, 2025 · The polysaccharide extract active hexose correlated compound (AHCC) of the Lentinula edodes mushroom has been tested in several human trials. 1 Lymphocytic GI lymphoma is an indolent disease that is usually Oct 1, 2025 · These guidelines have been approved by the four organizations that make up the Cooperating Parties for the ICD-10-CM: the American Hospital Association (AHA), the American Health Information Management Association (AHIMA), CMS, and NCHS. Because both AHCC and GCP have shown anti-tumor activities, their synergistic anti-tumor Apr 25, 2017 · Active hexose correlated compound (AHCC; Amino Up Chemical Co, Ltd, Sapporo, Japan) is a fermented extract prepared from mycelia of a Basidiomycete mushroom (Lentinula edodes) that has been proposed to have numerous health benefits mediated by both immunomodulatory and antitumor effects. Feb 4, 2024 · Active hexose-correlated compound (AHCC) was shown to be both directly and indirectly effective against chronic lymphocytic leukemia (CLL) in vitro and in vivo, according to a study published in Dec 18, 2023 · Importantly, macrophages expressing high levels of CD163 and CD86 have been observed in diffuse large B cell lymphoma [58], suggesting that the NLC phenotype may be seen in other B-cell malignancies and that AHCC may be effective there as well. The information in this book is for educational purposes only and is not recom-mended as a means of diagnosing or treating an illness. 1009 Studies have demonstrated that GCP has anti-angiogenesis and apoptosis induction effects in tumor. For more information, read the “What else do I need to know?” section below. Learn more about AHCC ® with direct access to the clinical studies completed about AHCC® and its effectiveness. Used in conjunction with chemotherapy and radiation, researchers found anemia prevention, hair loss prevention, and improvement in mood with those patients using AHCC. Data from the treatment of over 100,000 individuals with various types of cancer have shown AHCC ® treatment to be of benefit in 60% of cases. I’m going to cover 3 studies here and if you want more there will be resources at the end. AHCC is used widely in Japan for improving quality of life for cancer patient’s. Jul 9, 2025 · Mycomedicinals rarely cause side effects, but they should be used with caution in patients with leukemia and lymphoma, those who have recently had a bone marrow transplant, and people on immunosuppressants (due to mushrooms effects on immune modulation). However, the potential role of AHCC in tumor immune surveillance is unknown. No or too few reports of Follicle centre lymphoma, follicular grade i, ii, iii stage iv are found in people who take Ahcc. AHCC is often used as a supplement for improving the immune system and reducing the risk of cancer. Therapeutic Effects of Fucoidan against Human Bladder Cancer Feline large-cell lymphoma following previous treatment for small-cell gastrointestinal lymphoma: incidence, clinical signs, clinicopathologic data, treatment of a secondary malignancy, response and survival Jul 1, 2012 · Methods and patients Active hexose correlated compound (AHCC) and genistein concentrated polysaccharide (GCP) were administered to patients diagnosed with stage IV non-small cell lung cancer (NSCLC) with distant metastasis (M1). Large granular lymphoma is a subtype characterized by the presence of natural killer T lymphocytes that have characteristic intracytoplasmic granules. As a natural product, AHCC has potential to create safer adjuvant therapies in cancer patients. Read about the studies that have promoted AHCC as a leading extract for immunity. In this study, C57BL/6 mice were orally administered AHCC or water, followed by tumor cell inoculation. In this study, we determined the anti-cancer activity of fucoidan on diffuse large B cell lymphoma (DLBCL) cells both in vitro and in vivo. Learn more. 15) AHCC ® is particularly effective for liver, lung, stomach, colon, breast, thyroid, ovarian, testicular, tongue, kidney and pancreatic cancers. Mar 10, 2020 · The ASCO Post ’s Integrative Oncology series is intended to facilitate the availability of evidence-based information on integrative and complementary therapies sometimes used by patients with cancer. In this study, we demonstrate that AHCC enhances tumor immune surveillance against both melanoma and lymphoma formation by regulating both innate and adaptive immune responses. RESEARCHRecurrence prevention After Curative Hepatectomy of Hepatocellular Carcinoma AHCC® improved recurrence-free survival rate and hastened nutritional recovery in post-operative patients Curative hepatectomy is the standard treatment for advanced hepatocellular carcinoma. Our results suggest that AHCC may be a useful complementary therapy for treating certain cancers. Fucoidan is one of the major sulfated polysaccharides isolated from brown seaweeds. 7. Sep 30, 2020 · Gastrointestinal (GI) lymphoma can be divided histopathologically into low-grade (small-cell, lymphocytic) and intermediate- or high-grade (intermediate- or large-cell) types. Sep 24, 2025 · AHCC is an extract made from mushrooms that's been studied in humans for cancer, HPV, and liver disease. 15) One landmark AHCC Apr 1, 2004 · Abstract. . 2. 3882 Active Hexose Correlated Compound (AHCC) has been implicated to modulate immune functions and plays a protective role against infection. 2% β-glucans, which have a Mycomedicinals rarely cause side effects, but they should be used with caution in patients with leukemia and lymphoma, those who have recently had a bone marrow transplant, and people on immunosuppressants (due to mushrooms’ effects on immune modulation). Elevated nuclear β-catenin expression levels correlate with poor responses to standard of care and β-catenin regulates both tumor metabolism and the immune microenvironment. We study 160 people who take Follicle centre lymphoma, follicular grade i, ii, iii stage iv or have Ahcc. qpab4ltmh3krquxlqc09fvzu3xwhaenn4ihoxq6fwgoepqnmb